The common disease-common variant hypothesis suggests that common diseases, like autism or ADHD, are caused by a large number of gene variants that are relatively common in the population. Some of these variants can make a person more likely to develop certain conditions.
How can it impact a child's learning?
Shared genetic variations can influence how a child processes information or handles emotions.
Are these genetic variations common?
Yes, many people have these gene variations, making them quite prevalent in the population.
How can tools like visual schedules help kids impacted by this hypothesis?
Visual schedules provide structured routines, aiding kids in navigating challenges stemming from these genetic variations.
The common disease-common variant (CDCV) hypothesis posits that the genetic factors contributing to common diseases are attributable to a relatively large number of alleles that are prevalent in the population. According to this hypothesis, some of these variants confer susceptibility to complex polygenic diseases. The CDCV hypothesis, first proposed in the 1990s, has been extensively tested through genome-wide association studies (GWAS), which have provided valuable insights into the genetic underpinnings of neuropsychiatric disorders and potential shared pathways that may contribute to similar conditions.
The common disease-common variant hypothesis is used to:
| Application | Example |
|---|---|
| Genetic testing | Analyzing common variants to assess risk |
| Precision medicine | Tailoring treatments based on genetic profile |
By shedding light on the complex genetic architecture of common diseases, the CDCV hypothesis paves the way for more personalized approaches to diagnosis and intervention.
This post was originally published on August 19, 2023. It was updated on May 9, 2024.
