Chromosome 15q11-q13 is a part of chromosome 15 that has genes controlled by a process called genomic imprinting. This means that for these genes, only the copy from one parent works while the copy from the other parent is turned off. Problems in this region are linked to several disorders affecting the brain and behavior.
How common is Chromosome 15q11–q13 disorder?
It’s estimated that 1 in 10,000 to 25,000 people may have a deletion or duplication in this chromosome segment.
How can visual schedules assist kids with Chromosome 15q11–q13?
Visual schedules, like Goally, provide structure and predictability, aiding kids in understanding routines and building life skills.
Are there tools to help kids manage emotional regulation linked to Chromosome 15q11–q13?
Yes, apps like Goally offer emotional regulation tools to help kids identify, express, and manage their emotions effectively.
The 15q11-q13 region is a segment of chromosome 15 containing multiple genes subject to genomic imprinting, where gene expression occurs preferentially from one parental allele. Abnormalities in this chromosomal region, such as deletions, duplications, or uniparental disomy, are associated with various neurodevelopmental and neuropsychiatric conditions, including Prader-Willi syndrome, Angelman syndrome, and some cases of autism spectrum disorder. The prevalence of these disorders varies, with Prader-Willi and Angelman syndromes each occurring in approximately 1 in 15,000 to 30,000 individuals.
Chromosome 15q11-q13 disorders can cause a range of symptoms that vary depending on the specific condition and the individual child. Some common symptoms include:
| Prader-Willi Syndrome | Angelman Syndrome |
|---|---|
| Hypotonia (low muscle tone) | Developmental delays |
| Feeding difficulties in infancy | Intellectual disability |
| Hyperphagia (excessive hunger) | Absent or minimal speech |
| Obesity | Seizures |
| Behavioral issues | Happy demeanor with frequent laughter |
While the symptoms can be challenging, understanding your child’s unique needs and accessing appropriate support can make a big difference in their development and well-being.
This post was originally published on August 29, 2023. It was updated on May 8, 2024.
